The Wagner Laboratory

Ferraiuolo, R.-M. and K.-U. Wagner (2019): Regulation and new treatment strategies in breast cancer.

J. Life Sci. 1 (3): 23–38

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Essandoh, K.; S. Deng; X. Wang; M. Jiang; X. Mu; J. Peng; Y. Li; T Peng; K.-U. Wagner; J. Rubinstein and G.C. Fan (2019): Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.

FASEB J. 33 (6): 7451-7466

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Higazi, H.M.K.I.; L. He; J. Fang; F. Sun; Q. Zhou; T. Huang; X. He; Y. Wang; F. Xiong; P. Yang; Q. Yu; J. Li; K.-U. Wagner; B.L. Adam; S. Zhang and C.Y. Wang (2019): Loss of Jak2 protects cardiac allografts from chronic rejection by attenuating Th1 response along with increased regulatory T cells.

Am. J. Transl. Res. 11 (2): 624-640

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Wehde, B.L.; P.D. Rädler; H. Shrestha; S.J. Johnson; A.A. Triplett and K.-U. Wagner (2018):  Janus kinase 1 plays a critical role in mammary cancer progression.

Cell Rep. 25 (8): 2192–2207

Zboray K; J. Mohrherr; P. Stiedl; K. Pranz; L.Wandruszka; B. Grabner; R. Eferl;  R. Moriggl; D. Stoiber; K. Sakamoto; K.-U. Wagner; H. Popper; E. Casanova and H.P. Moll (2018): AKT3 drives adenoid cystic carcinoma development in salivary glands.

Cancer Med. 7 (2): 445-453

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Rädler, P.D.; B.L. Wehde and K.-U. Wagner (2017): Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.

Mol. Cell. Endocrinol. 451: 31-39

Rajbhandari, N.; W.C. Lin; B.L. Wehde, A.A. Triplett and K.U. Wagner (2017): Autocrine IGF1 signaling mediates pancreatic tumor cell dormancy in the absence of oncogenic drivers.

Cell Rep. 18 (9): 2243-2255

Asshoff, M.; V. Petzer; M.R.Warr; D. Haschka; P. Tymoszuk; E. Demetz; M. Seifert; W. Posch; M. Nairz; P. Maciejewski; P. Fowles; C.J. Burns; G. Smith; K.U. Wagner; G. Weiss; J.A. Whitney and I. Theurl (2017): Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production and ameliorates anemia of chronic disease in rodents.

Blood 129 (13): 1823-1830

Desai, H.R.; T. Sivasubramaniyam; X.S. Revelo; S.A. Schroer; C.T. Luk; P.R. Rikkala; A.H. Metherel; D.W. Dodington; Y.J. Park; M.J. Kim; J.A. Rapps; R. Besla; C.S. Robbins;  K.-U. Wagner; R.P. Bazinet; D.A. Winer and M. Woo (2017): Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

Sci. Rep. 7 (1): e7653

Sivasubramaniyam, T.; S.A. Schroer; A; A. Li; C.T. Luk; S.Y. Shi; R. Besla; D.W. Dodington; A.H. Metherel; A.P. Kitson; J.J. Brunt; J. Lopes; K.-U. Wagner; R.P. Bazinet; M.P. Bendeck; C.S. Robbins and M. Woo (2017): Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

JCI Insight. 2 (14): e93735

Shi, S.Y.; S.A. Schroer; C.T. Luk; M.J. Kim; D.W. Dodington; L. Lin; T. Sivasubramaniyam; E.P. Cai; S.Y. Lu; K.U. Wagner; R.P. Bazinet and M. Woo (2017): Janus kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.

J. Biol. Chem. 292 (9): 3789-3799

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Mukhopadhyay, C.; A.A. Triplett; T. Bargar; C. Heckman; K.-U. Wagner and M. Naramura (2016): Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.

Proc. Natl. Acad. Sci. U.S.A. 113 (51): E8228-E8237

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Themanns, M.; K.M. Mueller; S.M. Kessler; N. Golob-Schwarzl; T. Mohr; D. Kaltenecker; J. Bourgeais; J. Paier-Pourani; K. Friedbichler; D. Schneller; M. Schlederer; E. Zebedin-Brandl; L.M. Terracciano; X. Han; L. Kenner; K.-U. Wagner; W. Mikulits; A.V. Kozlov; M.H. Heim; F. Gouilleux; J. Haybaeck and R. Moriggl (2016): Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

Sci. Rep. 6:34719

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Sakamoto, K.; B.L. Wehde; P.D. Rädler; A.A. Triplett and K.-U. Wagner (2016): Generation of Janus kinase 1 (JAK1) conditional knockout mice.

Genesis 54 (11): 582-588

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Walker, W.P.; A. Oehler; A.L. Edinger; K.-U. Wagner and T.M. Gunn TM (2016): Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.

Biol. Cell. 108 (11): 324-337

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Sakamoto, K.; B.L. Wehde; K.H. Yoo; T. Kim; N. Rajbhandari; H.Y. Shin; A.A. Triplett; P.D. Rädler; F. Schuler; A. Villunger; K. Kang; L. Hennighausen and K.-U. Wagner (2016): Janus kinase 1 is essential for inflammatory cytokine signaling and mammary gland remodeling.

Mol. Cell. Biol. 36 (11): 1673-1690

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Gan, X.T.; V. Rajapurohitam ; J. Xue; C. Huang; S. Bairwa; X. Tang; J.T. Chow; M.F. Liu; F. Chiu; K. Sakamoto; K.-U. Wagner and M. Karmazyn (2015): Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.

Am. J. Pathol. 185 (12): 3202-3210

Klein, S; J. Rick;, J. Lehmann; R. Schierwagen; I.G. Schierwagen; L. Verbeke; K. Hittatiya; F.E. Uschner; S. Manekeller; C.P. Strassburg. K.-U. Wagner; P.P. Sayeski; D. Wolf; W. Laleman; T. Sauerbruch and J. Trebicka (2017): Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.

Gut 66 (1): 145-155 (Epub Sep 17, 2015!)

Sánchez-Bailón, M.P.; A. Calcabrini; V. Mayoral-Varo; A. Molinari, K.-U. Wagner; J.P. Losada; S. Ciordia; J.P. Albar and J. Martín-Pérez (2015): Cyr61 as mediator of Src signaling in triple negative breast cancer cells.

Oncotarget 6 (15): 13520-13538

Witkiewicz, A.K.; E.A. McMillan; U. Balaji; G. Baek; W.-C. Lin; J. Mansour; M. Mollaee. K.-U. Wagner, P. Koduru; A. Yopp; M.A. Choti; C.J. Yeo; P. McCue; M.A. White and E.S. Knudsen  (2015): Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. 

Nature Communications 6: 6744  

Das S.; S. Rachagani; M.P. Torres-Gonzalez; I. Lakshmanan; P.D. Majhi; L.M.Smith; K.-U. Wagner and S.K. Batra (2015): Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic phenotypes through nuclear translocation of JAK2 to pancreatic cancer cells. 

Oncotarget 6 (8): 5772-87  

Sakamoto, K.; J.W. Schmidt and K.-U. Wagner (2015):  Mouse models for breast cancer. 

Methods Mol Biol. 1267: 47-71 

Joshi, S.; S. Kumar; S. Bafna; S. Rachagani; K.-U. Wagner; M. Jain and S.K. Batra (2015): Genetically engineered mucin mouse models for inflammation and cancer. 

Cancer Metastasis Rev. 34 (4): 593-609

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Sakamoto, K.; C.B. Gurumurthy and K.-U. Wagner (2014): Generation of conditional knockout mice. 

Methods Mol Biol. 1194: 21-35 

Grundschober. E.; A. Hoelbl-Kovacic; N. Bhagwat; B. Kovacic; R. Scheicher; E. Eckelhart; K. Kollmann; M. Keller; F. Grebien; K.-U. Wagner, R.l; Levine and V. Sexl (2014): Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells. 

Leukemia 28 (9): 1918-1922  

Akada, H.; S. Akada; R.E. Hutchison; K. Sakamoto; K.-U. Wagner and G. Mohi (2014): Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells. 

Stem Cells 32 (7): 1878-1889  

Lin W.C..; N. Rajbhandari and K.-U. Wagner (2014): Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies. 

Cancer Research 74 (8): 2138-2143 

Schmidt, J.W.; B.L. Wehde;  K. Sakamoto; A.A. Triplett; S.M. W.W. West and K.-U. Wagner (2014): Novel transcripts from a distinct promoter that encode the full-length Akt1 in human breast cancer cells. 

BMC Cancer 14 (1):195

Grisouard J.; H. Hao-Shen; S. Dirnhofer; K.-U. Wagner and R.C. Skoda (2014): Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia. 

Haematologica 99 (4): e52-54 

Schmidt, J.W.; B.L. Wehde;  K. Sakamoto; A.A. Triplett; S.M. Anderson; P.N. Tsichlis; G. Leone and K.-U. Wagner (2014):  Stat5 regulates the PI3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. 

Mol. Cell. Biol. 34 (7):1363-1377  

Zhang, Q.; K. Sakamoto and K.-U. Wagner (2014): D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells. 

Mol. Cell. Endocrinol. 382: 583–592  (Epub April 4, 2013) 

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Nordstrom, S.M.; J.L. Tran; B.C. Sos; K.-U. Wagner and E.J. Weiss (2013): Disruption of JAK2 in adipocytes impairs Lipolysis and Improves Fatty Liver in Mice With Elevated GH. 

Molecular Endocrinology 27 (8): 1333-1342 

Yang, P.; Y. Zhang;  J. Pang; S. Zhang;  Q. Yu; L. He; K.-U. Wagner; Z. Zhou and C.-Y. Wang (2013): Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities. 

Am. J. Pathol. 183 (2): 617-625 

Xin, H.; R. Lu; H. Lee; W. Zhang; C. Zhang; J. Deng; Y. Liu; S. Shen;  K.-U. Wagner; S. Forman; R. Jove and H. Yu (2013: G-protein coupled receptor agonist BV8/prokineticin-2 and STAT3 form a feed-forward loop in both normal and malignant myeloid cells. 

J. Biol. Chem. 288 (19): 13842-13849 

Lin, W.C. ‡; J.W. Schmidt ‡; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2013): Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung. 

PLoS ONE 8 (4): e60902    ‡ contributed equally

Park, S.O.; H.L. Wamsley; K. Bae; Z. Hu; X. Li; S.W. Choe; W.B. Slayton; S.P. Oh; K.-U. Wagner and  P.P Sayeski (2013): Conditional Deletion of Jak2 Reveals an Essential Role in Hematopoiesis throughout Mouse Ontogeny: Implications for Jak2 Inhibition in Humans. 

PLoS ONE 8 (3): e59675 

Lin, W.C.; N. Rajbhandari; C. Liu; K. Sakamoto; Q. Zhang; A.A. Triplett; S.K. Batra; R. Opavsky; D.W. Felsher;  D.J. DiMaio; M.A. Hollingsworth; J.P. Morris 4th; M. Hebrok; A.K. Witkiewicz; J.R. Brody; H.Rui and K.-U. Wagner (2013): Dormant cancer cells contribute to residual disease in a mouse model for reversible pancreatic cancer. 

Cancer Research 73 (6): 1821-1830                     Supplementary Data

Bell, B.D.; M. Kitajima; R.P. Larson; T.A. Stoklasek; K. Dang; K. Sakamoto; K.-U. Wagner; B. Reizis; L. Hennighausen and S.F. Ziegler (2013): STAT5 is critical in Dendritic Cells for development of TH2- but not TH1-dependent Immunity.

Nature Immunology 14 (4): 364-371

Kubovcakova, L.; P. Lundberg; J. Grisouard; H. Hao-Shen; V. Romanet; R. Andraos; M. Murakami; S. Dirnhofer; K.-U. Wagner; T. Radimerski, and R.C. Skoda (2013): Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model. 

Blood 121 (7): 1188-1199 

Wagner, K.-U.; B.W. Booth; C.A. Boulanger and G.H. Smith (2013): Multipotent PI-MECs are the true targets of MMTV-neu tumorigenesis. 

Oncogene 32 (10): 1338 

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Rachagani, S; M.P. Torres; S. Kumar; D. Harida; M. Baine; M.A. Macha; S. Kaur; M.P. Ponnusamy; P. Dey; P. Seshacharyulu; S.L. Johansson; M. Jain;  K.-U. Wagner and S.K Batra (2012): Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy. 

J. Hematol. Oncol. 5 (1): 68 

Sakamoto, K.; J.W. Schmidt and K.-U. Wagner (2012): Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. 

PLoS ONE 7 (8): e43778 

Sánchez-Bailóna, M.P.; A. Calcabrinia; D. Gómez-Domíngueza; B. Mortec; E. Martín-Foreroa; G. Gómez-Lópezd; A. Molinarib; K.-U. Wagner and J. Martín-Péreza (2012): Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells. 

Cellular Signalling 24: 11276–1286 

Morris, C.R.; M.J. Stanton; K.C. Manthey; K.B. Oh and K.-U. Wagner (2012): A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death. 

PLoS ONE 7 (3): 34308 

Hantschel, O.; W. Warsch; E. Eckelhart; I. Kaupe; F. Grebien; K.-U. Wagner; G. Superti-Furga and V. Sexl (2012): Targeting STAT5 in CML: Mechanism-of-action of JAK2 tyrosine kinase inhibitors in CML unmasks a direct BCR-ABL/STAT5 axis. 

Nature Chemical Biology 8 (3): 285-293 

Shi, S.Y.; R. Garcia Martin; R.E. Duncan; D. Choi; S.Y. Lu;,S.A.Schroer; E.P. Cai; C.T. Luk; K.E. Hopperton; A.F. Domenichiello; C. Tang; M. Naples; M.J. Dekker; A. Giacca; K. Adeli; K.-U.Wagner; R.P. Bazinet and M. Woo (2012): Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.

J. Biol. Chem. 287 (13): 10277-10288 

Hlady, R.A.; S. Novakova; J. Opavska; D. Klinkebiel; S.L. Peters; J.Bies; J. Hannah; J. Iqbal; K.M. Anderson; H.M. Siebler; L.M. Smith; T.C. Greiner; D. Bastola; S. Joshi; O. Lockridge; M.A. Simpson; D.W. Felsher; K.-U. Wagner; W.C. Chan; J.K. Christman and R. Opavsky (2012): Loss of Dnmt3b maintenance function up-regulates the novel tumor modifier Ment and accelerates mouse. lymphomagenesis. 

J. Clin. Invest. 122 (1): 163-177 

Schmidt, J.W. and K.-U. Wagner (2012):  Activation of Janus Kinases During Tumorigenesis in “Jak-Stat Signaling: From Basics to Disease”; edited by Decker, T. and Muller, M., Springer Publishing, ISBN: 978-3-7091-0890-1, Pgs. 259-288 

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Schneckenleithner, C.; Z. Bago-Horvath; H. Dolznig; N. Neugebauer; K. Kollmann; T. Kolbe; T. Decker; D. Kerjaschki; K.-U.Wagner; M. Müller; D. Stoiber and V. Sexl (2011): Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias. 

Oncotarget 2 (12): 1043-1054 

Wagner, K.-U. and J.W. Schmidt (2011): The two faces of Janus kinases and their respective STATs in mammary gland development and cancer. 

Journal of Carcinogenesis 10 (32): 50-59 

Zhang, Q.; K. Sakamoto; C. Liu; A.A. Triplett; W.C. Lin; H. Rui and K.-U. Wagner (2011): Cyclin D3 compensates for the loss of Cyclin D1 during ErbB2-induced mammary tumor initiation and progression. 

Cancer Research 71 (24): 7513-7524 

Tu, C.; G. Ahmad; B. Mohapatra; S. Bhattacharyya; C.F. Ortega-Cava; B.M. Chung; K.-U. Wagner; S.M. Raja; M. Naramura; V. Band and H. Band (2011): ESCRT proteins: double-edged regulators of cellular signaling. 

BioArchitecture 1 (1): 45-48 

Pathak, S.; S. Ma; L. Trinh; J. Eudy; K.-U. Wagner; S.S. Joshi and R. Lu (2011): IRF4 is a suppressor of c-Myc induced B cell leukemia. 

PLoS ONE 6 (7): e22628

Mueller, K.M.; J.-W. Kornfeld; K. Friedbichler; L. Blaas; G. Egger; H. Esterbauer; P. Hasselblatt; M. Schlederer; S. Haindl; K.-U. Wagner; D. Engblom; G. Haemmerle; D. Kratky; V. Sexl; L. Kenner; A.V. Kozlov; L. Terracciano; R. Zechner; G. Schuetz; E. Casanova; J.A. Pospisilik; M.H. Heim and R. Moriggl (2011): Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. 

Hepatology 54 (4): 1398-1409

Nordstrom, S.M.; J.L. Tran; B.C. Sos; K.-U. Wagner and E. J. Weiss (2011): Liver-derived IGF-1 contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH. 

Molecular Endocrinology 25 (7): 1223-1230 

Kirabo, A.; S.P. Oh; H. Kasahara; K.-U. Wagner and P.P. Sayeski (2011): Vascular Smooth Muscle Jak2 Deletion Prevents Angiotensin II-induced Neointima Formation Following Injury in Mice. 

Journal of Molecular and Cellular Cardiology 50 (6): 1026-10234 

Sos, B.C; C. Harris; S.M. Nordstrom; J.L. Tran; M. Balázs; P. Caplazi; M. Febbraio; M.A. Applegate; K.-U. Wagner and E.J. Weiss (2011): Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2

J. Clin. Invest. 121 (4): 1412-1423 

Kirabo, A.; P.N. Kearns; Y.P. Jarajapu; J.M. Sasser; S.P. Oh; M.B. Grant; H. Kasahara; A.J. Cardounel; C. Baylis; K.-U. Wagner and P.P. Sayeski (2011): Vascular Smooth Muscle Jak2 Mediates Angiotensin II-induced Hypertension via Increased Levels of Reactive Oxygen Species. 

Cardiovascular Research 91 (1): 171-179 

Rucker, E.B.; A.N. Hale; D.C. Durtschi; K. Sakamoto and K.-U. Wagner (2011): Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax. 

Genesis 49 (1): 24-35 

Wu S.; S. Divall; G.E. Hoffman; W.W. Le; K.-U. Wagner and A. Wolfe (2011): Jak2 is Necessary for Neuroendocrine Control of Female Reproduction. 

Journal of Neuroscience 31 (1): 184-192 

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Choi, D.; S.A. Schroer; S.Y. Lu; L. Wang; X. Wu; Y. Liu; Y. Zhang; H.Y. Gaisano; K.-U. Wagner; H. Wo; R. Retnakaran and M. Wo (2010): Erythropoietin protects against diabetes through direct effects on pancreatic β cells. 

J. Exp. Med. 207 (13): 2831-2842

Rochman, Y; M. Kashyap; G.W. Robinson; K. Sakamoto; J. Gomez-Rodriguez; K.-U. Wagner and W.J. Leonard (2010): Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. 

Proc. Natl. Acad. Sci. U.S.A 107 (45): 19455-19460 

Tu, C.; C.F. Ortega-Cava; P. Winograd; M.J. Stanton; A.L. Reddi; I. Dodge; R. Arya; M. Dimri; R.J. Clubb; M. Naramura; K.-U. Wagner; V. Band and H. Band (2010): Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent late endosome/lysosome traffic regulates the localization of active Src at focal adhesions. 

Proc. Natl. Acad. Sci. U.S.A. 107 (37): 16107-16112 

Sakamoto, K; A.A. Triplett; L.A. Schuler and K.-U. Wagner (2010): Jak2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. 

Oncogene 29 (39): 5359-5369     Supplementary Data

Creamer, B.A.; K. Sakamoto; J.W. Schmidt; A.A. Triplett, R. Moriggl and K.-U. Wagner (2010): Stat5 promotes survival of mammary epithelial cell through transcriptional activation of a distinct promoter in Akt1. 

Mol. Cell. Biol. 30 (12): 2957–2970 

Yalcin-Ozuysal, O; M. Fiche; M. Guitierrez; K.-U. Wagner; W. Raffoul and C. Brisken (2010): Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. 

Cell Death Differ. 17 (10): 1600–1612 

Zhang, Q.‡; A.A. Triplett‡; D.W. Harms. W.C. Lin; B.A. Creamer; A. Rizzino and K.-U. Wagner (2010): Temporally and spatially controlled expression of transgenes in embryonic and adult tissues. 

Transgenic Research 19 (3): 499-509   ‡contributed equally   Supplementary Data

Sakamoto, K.; W.C. Lin; A.A. Triplett and K.-U. Wagner (2009): Targeting Jak2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy. 

Cancer Research 69 (16): 6642-6650      Supplementary Data

Creamer, B.A.; A.A. Triplett and K.-U. Wagner (2009): Longitudinal analysis of mammogenesis using a novel tet-inducible mouse model and in vivo imaging. 

Genesis 47 (4): 234-245 

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Triplett, A.A.; Montagna, C. and K.-U. Wagner (2008): A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis. 

Neoplasia 10 (12): 1325–1334 

Bierie, B.; D.G. Stover; T.W. Abel; A. Chytil; A.E. Gorska; M. Aakre; E. Forrester; L. Yang; K.-U. Wagner and H.L. Moses (2008): Transforming Growth Factor- b Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment. 

Cancer Research 68 (6): 1809-19 

Wagner, K.-U . and H. Rui (2008): Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. 

Journal of Mammary Gland Biology and Neoplasia 13 (1): 93-103

Lin, D.I.; M.D. Lessie; A.B. Gladden; C.H. Bassing; K.-U. Wagner and J.A. Diehl (2008): Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis. 

Oncogene 27 (9): 1231–1242 

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Feng, Y.; D. Manka; K.-U. Wagner and S. Khan (2007): ERa expression in the mammary epithelium is required for ductal and alveolar morphogenesis in pubertal, pregnant and lactating mice. 

Proc. Natl. Acad. Sci. U.S.A. 104 (37): 14718 –14723 

Neilson, L.M.; J. Zhu; J. Xie; M.G. Malabarba; K. Sakamoto ; K.-U. Wagner; R.A. Kirken and H. Rui (2007): Coactivation of Jak1 Positively Modulates Prolactin-Jak2 Signaling in Breast Cancer: Recruitment of ERK and Stat3 and Enhancement of Akt and Stat5a/b Pathways. 

Molecular Endocrinology 21 (9): 2218–2232 

Pecha, J.; D. Ankrapp; C. Jiang; W. Tang; K. Bruck; K.-U. Wagner and H. Xiao (2007): Deletion of Tip30 leads to rapid immortalization of murine mammary epithelial cells and ductal hyperplasia in the mammary gland. 

Oncogene 26 (53): 7423-7431 

Sakamoto, K; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2007): The Janus kinase 2 (Jak2) is required for expression and nuclear accumulation of Cyclin D1 in proliferating mammary epithelial cells. 

Molecular Endocrinology 21 (8): 1877-1892 

Oh, K.B.; M.J. Stanton; W.W. West; G.L. Todd and K.-U. Wagner (2007): Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. 

Oncogene 26 (40): 5950–5959 

Matulka, L.A.; A.A. Triplett and K.-U. Wagner (2007): Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells. 

Developmental Biology 303 (1): 29–44 

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Loladze A.V.; M.A. Stull; A.M. Rowzee; J. Demarco; J.H. Lantry, 3 rd; C.J. Rosen; D. Leroith; K.-U. Wagner; L. Hennighausen and T.L Wood (2006): Epithelial-Specific and Stage-Specific Functions of IGF-I during Postnatal Mammary Development. 

Endocrinology 147 (11): 5412-5423 

Utama, F.E.; M.J. LeBaron; L.M Neilson; A.S. Sultan; A.F. Parlow; K.-U. Wagner and H. Rui (2006): Human prolactin receptors are insensitive to mouse prolactin: Implications for xenotransplant modeling of human breast cancer in mice.

Journal of Endocrinology 188 (3): 589-601 

Triplett, A.A.; K. Sakamoto; L.A. Matulka; L. Shen; G.H. Smith and K.-U. Wagner (2005): Expression of the Whey Acidic Protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells. 

Genesis 43 (1): 1-11 

Matulka, L.A. and K.-U. Wagner (2005): Models of Breast Cancer. 

Drug Discovery Today: Disease Models 2 (1): 1-6

Wagner, K.-U. and G. H. Smith (2005): Pregnancy and Stem Cell Behavior. 

Journal of Mammary Gland Biology and Neoplasia 10 (1): 25-36 

Sum, E.Y.M.; M. Shackleton; L.A. O’Reilly; K. Hahm; N.K. Jonas; K.-U. Wagner; G.J. Lindeman and J.E. Visvader (2005): The LIM domain protein Lmo4 is highly expressed in epithelial tissues and influences lobuloalveolar development in the mammary gland. 

Oncogene 24 (30): 4820-4828 

Boulanger , C.A. ; K.-U. Wagner and G.H. Smith (2005): Parity-induced mouse mammary epithelial cells (PI-MEC) are pluripotent, self-renewing and sensitive to TGF-b1 expression. 

Oncogene 24 (4): 552-560 

Amit, I.; K.-U. Wagner and Y. Yarden (2005): Molecular functions of Tsg101. Chapter 1 in “Second Messengers and Phosphoprotein Signaling”; pp 1-11; edited by M.B. Anand-Srivastava, M. Tremblay, and A.K. Srivastava; Medimont S.r.l., Bologna, Italy

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Sgagias, M.K.; K.-U. Wagner; B. Hamik; S. Stoeger ; R. Spieker; L.J. Huber; L.A. Chodosh and K.H. Cowan (2004): Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS. 

Cell Cycle 3 (11): 1451-1456 

Krempler, A.; Y. Qi; A.A. Triplett; J. Zhu; H. Rui and K.-U. Wagner (2004): Generation of a conditional knockout allele for the Janus Kinase 2 (Jak2) gene in mice. 

Genesis 40 (1):52-57 

Henry, M.D.; A.A. Triplett; K.B. Oh; G.H. Smith and K.-U. Wagner (2004): Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice. 

Oncogene 23 (41): 6980–6985 

Carstens; M.J.; A. Krempler; A.A. Triplett; M. van Lohuizen and K.-U. Wagner (2004): Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. 

J. Biol. Chem. 279 (34): 35984-35994 

Wagner, K.-U.; A. Krempler; A.A. Triplett, Y. Qi; N.M. George; J. Zhu and H. Rui (2004): Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. 

Mol. Cell. Biol. 24 (12): 5510-5520

Cheung, A.M.Y.; A. Elia; M.-S. Tsao; S. Done; K.-U. Wagner; L. Hennighausen; R. Hakem and T.W. Mak (2004): Brca2 deficiency does not impair mammary gland development but promotes the development of mammary adenocarcinomas in p53+/- mutant mice. 

Cancer Research 64 (6): 1959-1965 

Backman, S.A.; D. Ghazarian; K. So; O. Sanchez; K.-U.Wagner; L. Hennighausen; A. Suzuki; M.S. Tsao; W.B. Chapman; Backman SA, Ghazarian D, So K, Sanchez O, Wagner KU, Hennighausen L, Suzuki A, Tsao MS, Chapman WB, Stambolic V, Mak TW. Stambolic and T.W. Mak (2004): Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. 

Proc. Natl. Acad. Sci. U.S.A. 101 (6): 1725-1730 

Wagner, K.-U. (2004): Quo Vadis, Animal Modeling? 

Breast Cancer Research 6 (1): 31-38  (online 31 October 2003)

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Long, W.; K.-U. Wagner; K.C.K. Lloyd; L.N. Binart; J. M. Shillingford; L. Hennighausen and F.E. Jones (2003):
Impaired mammopoiesis and Stat5 activation in mice with conditional ErbB4 mutations. 

Development 130 (21): 5257-5268 

Bierie, B.; M. Nozawa; J.-P. Renou; J. M. Shillingford; F. Morgan; T. Oka; M. M. Taketo; R. D. Cardiff; K. Miyoshi; K.-U. Wagner; G. W. Robinson and Lothar Hennighausen (2003): Activation of b-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. 

Oncogene 22 (25): 3875-3887 

Seagroves T.N.; D. Hadsell; J. McMananman; C. Palmer; D. Liao; W. McNulty; B. Welm; K.-U. Wagner; M. Neville and R..S. Johnson (2003): HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. 

Development 130 (8): 1713-1724 

Wagner, K.-U., A. Krempler, Y. Qi, K. Park, M. D. Henry, A. A. Triplett, G. Riedlinger, E. B. Rucker III, and L. Hennighausen (2003): Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues.

Mol. Cell. Biol. 23 (1): 150-162 

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Krempler, A.; M. D. Henry; A. A. Triplett and K.-U. Wagner (2002): Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53 independent cell death. 

J. Biol. Chem. 277 (45): 43216-43223 

Li, G.; G.W Robinson; R. Lesche; H. Martinez-Diaz; Z. Jiang; N. Rozengurt; K.-U. Wagner; D.C. Wu; T.F. Lane; X. Liu; L. Hennighausen and H. Wu (2002): Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. 

Development 129 (17): 4159-4170 

Nevalainen, M. T.; J. Xie; L. Bubendorf; K.-U. Wagner and H. Rui (2002): Basal activation of transcription factor Stat5 in nonpregnant mouse and human breast epithelium. 

Molecular Endocrinology 16 (5): 1108-1124 

Cui Y.; K. Miyoshi; E. Claudio; T. Oka; U.K. Siebenlist; F.J. Gonzalez; J. Flaws; K.-U. Wagner; and L. Hennighausen (2002): Loss of the peroxisome proliferation-activated receptor gamma does not affect mammary development and propensity for tumor formation but leads to reduced fertility. 

J. Biol. Chem. 277 (20): 17830-17835 

Wagner, K.-U.; C. A. Boulanger; M. D. Henry; M. Sgagias, L. Hennighausen, and G. H. Smith (2002): An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal. 

Development 129 (6): 1377-1386

Riedlinger, G.; R. Okagaki; K.-U. Wagner; E. B. Rucker; T. Oka; K. Miyoshi; J. A. Flaws and L. Hennighausen (2002): Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary.

Biology of Reproduction 66 (2): 438-444 

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Miyoshi, K.; J. Shillingford; G. H. Smith; S. Grimm; K.-U. Wagner; T. Oka; J. M. Rosen; G. W. Robinson and L. Hennighausen (2001): Signal Transducer and Activator Transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. 

Journal of Cell Biology 155 (4): 531-542 

Walton K. D., K.-U. Wagner, E. B. Rucker, J. M. Shillingford, and L. Hennighausen (2001): Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation. 

Mechanisms of Development 109 (2): 281-293 

Robinson, G.W.; K.-U. Wagner; and L. Hennighausen (2001): Functional mammary gland development and tumor formation are not affected by the absence of the retinoblastoma gene. 

Oncogene 20 (48): 7115-7119 

Wagner, K.-U.; K. McAllister; T. Ward; B. Davis; R. Wiseman and L. Hennighausen (2001): Spatial and temporal expression of the Cre gene under the control of the MMTV LTR in different transgenic lines. 

Transgenic Research 10 (6): 545-553 

Yamashita H., M. T. Nevalainen, J. Xu, M. J. LeBaron, K.-U. Wagner, R. A. Erwin, J. M. Harmon, L. Hennighausen, R. A. Kirken, and H. Rui (2001): Role of serine phosphorylation of Stat5a in prolactin-stimulated b-casein gene expression.

Molecular and Cellular Endocrinology 183 (1-2): 151-63 

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Wagner, K.-U.; E. Claudio; E.B. Rucker III; G. Riedlinger; C. Broussard; P. L. Schwarzberg; U. Siebenlist and L. Hennighausen (2000): Conditional deletion of the bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. 

Development 127 (22): 4949-4958

Rucker. E.B. III, P. Dierisseau, K.-U. Wagner, L. Garrett, A. Wynshaw-Boris, J. A. Flaws and L. Hennighausen (2000): Survival of primordial germ cells during mouse embryogenesis is dependent on Bcl-x. 

Molecular Endocrinology 14 (7): 1038-1052 

Wagner, K.-U., E. B. Rucker III and L. Hennighausen (2000): Adenoviral and transgenic approaches for the conditional deletion of genes from mammary tissue. Chapter 24 in "Methods in mammary gland biology and breast cancer"; pp 271-288; edited by Ip, M.M. and Asch, B.B.; Kluwer Academic/Plenum Publishers, New York; ISBN: 0-306-46397-0.

Li, M., K.-U. Wagner, and P.A. Furth (2000): Transfection of primary mammary epithelial cells by viral and nonviral methods. Chapter 21 in "Methods in mammary gland biology and breast cancer"; pp 233-244; edited by Ip, M.M. and Asch, B.B.; Kluwer Academic/Plenum Publishers, New York; ISBN: 0-306-46397-0.

Xu X., K.-U. Wagner, D. Larson, Z. Weaver, C. Li, T. Ried, L. Hennighausen, A. Wynshaw-Boris, and C.-X. Deng (1999): Conditional knockout of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumor formation.

Nature Genetics 22 (1): 37-43 

Wagner, K.-U.; Dierisseau, P. and L. Hennighausen (1999): Assignment of the murine tumor susceptibility gene 101 (tsg101) and a processed tsg101 pseudogene (tsg101-ps1) to mouse chromosome 7 band B5 and chromosome 15 band D1 by in situ hybridization. 

Cytogenet Cell Genet 84 (1-2): 87-88 

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Wagner, K.-U.; Dierisseau, P.; Rucker, E.B., III; Robinson, G. W. and L. Hennighausen (1998): Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: Common types of shorter transcripts are true alternative splice variants. 

Oncogene 17 (21): 2761-2770 

Young, W.S.; Shepard, E.; DeVries, A.C.; Zimmer, A.; LaMarca, M.E.; Ginns, E.I.; Amico, J.; Nelson, R.J.; L. Hennighausen and K.-U. Wagner (1998): Targeted reduction of oxytocin expression provides insights into its physiological roles (Review). 

Adv. Exp. Med. Biol. 449: 231-240 

Wagner, K.-U.; W. S. Young; X. Liu; E. I. Ginns; M. Li; P. A. Furth and L. Hennighausen (1997): Oxytocin and milk removal are required for post-partum mammary gland development. 

Genes and Function 1 (4): 233-244 

Wagner, K.-U.; R.J. Wall; L. St-Onge; P. Gruss; A. Wynshaw-Boris; M. Li; P.A. Furth and L. Hennighausen (1997): Cre mediated gene deletion in the mammary gland. 

Nucleic Acids Res. 25 (21): 4323-4330 

Hennighausen, L.; G. W. Robinson; K.-U. Wagner and X. Liu (1997): Developing a mammary gland is a Stat affair. 

Journal of Mammary Gland Biology and Neoplasia 2 (4): 365-372

Hennighausen, L.; G. W. Robinson, K.-U. Wagner and X. Liu (1997): Prolactin Signalling in Mammary Gland Development. 

J. Biol. Chem. 272 (12): 7567-7569 

Li, M.; X. Liu; G. W. Robinson; U. Bar-Peled; K.-U. Wagner; W. S. Young; E. I. Ginns; L. Hennighausen and P. A. Furth (1997): Mammary derived signals activate programmed cell death in the involuting gland. 

Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3425-3430 

Liu X.; .G.W. Robinson; K.-U. Wagner; L. Garrett; A. Wynshaw-Boris and Lothar Hennighausen (1997): Stat5a is mandatory for adult mammary gland development and lactogenesis. 

Genes and Development 11 (2): 179-186 

Young, W.S.; E. Shepard; J. Amico; L. Hennighausen; K.-U. Wagner; M.E. LaMarca; C. McKinney and E.I. Ginns (1996): Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. 

J. Neuroendocrinol. 8 (11): 847-853 

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